GABA Myotonic Dystrophy Skeletal muscle Neuron Gene Therapy Dystrophie Myotonique BIOLOGIE MOLECULAIRE Duchenne muscular dystrophy Mouse models RNA interference Alternative splicing Brain ARN Central nervous system Myostatin Glial cells Humans Mice Animals Astrocytes Therapy Gene therapy Trinucleotide Repeat Expansion Transgenic mouse RNA biology Quantitative microdialysis Male Exercise Muscle CONGENITAL MYATHENIC SYNDROME Dystrophin CRISPR/Cas9 Intermediate filament Heart Trinucleotide repeat expansion PacBio Acetylcholinesterase knockout mouse Glutamate Acetylcholinesterase deficiency Dystrophie myotonique DMSXL mice Myotonic dystrophy type 1 Antisense oligonucleotides CTG repeat contractions Muscular dystrophy DM1 Desmin Dilated cardiomyopathy Transcriptomics Fibrosis Genotype phenotype correlation Motoneuron Astrocyte Acute coronary syndrome Expression Transgenic mouse model Knockout Maximal force RNA splicing Cytoskeleton Myelin MBNL Glucocorticoid-receptor AAV Cell model Myotonic dystrophy mouse models CRISPRi Aging Thérapie génique Brain dysfunction Autophagy PCR Myotonic Dystrophy type 1 KNOCKOUT MICE In vivo Glucocorticoids CTG repeat instability ACETYLCHOLINESTERASE Cardiac muscle Oligodendrocyte Mouse model Cell penetrating peptide DMPK Heart failure Dynamin 2 Gene editing CMS CTG repeats GSK3␤ Lc3 Antisense oligonucleotide Diaphragm Oligodendrocytes Myotonic dystrophy Hypoxia Centronuclear myopathy Myotonic Dystrophy Type 1 Exercice Cell culture model Long read sequencing