Skip to Main content Skip to Navigation
Journal articles

Obesity in Pediatric-Onset Multiple Sclerosis

Abstract : Objective To study the link between a high body mass index (BMI) in childhood and the occurrence of pediatric-onset multiple sclerosis (POMS) and to compare, within the MS population, the clinical-radiologic-biological characteristics, according to BMI. Methods A case-control study comparing BMI data of 60 patients with POMS (39 girls and 21 boys) at Bicêtre Hospital with that of 113 non-neurologic controls NNCs (68 girls and 45 boys) and 18,614 healthy controls HCs (9,271 girls and 9,343 boys) was performed. Crude BMI (cBMI), residual BMI (rBMI = measured BMI − expected BMI for age), z-score (rBMI/SD), and adult equivalent categories (International Obesity Task Force ≥25 = overweight, ≥30 = obese) were assessed. Results In boys, cBMI and rBMI were significantly higher in patients with POMS compared with NNCs (cBMI: +2.9; rBMI: +2.95, p < 0.01) and HCs (cBMI: +2.04, p < 0.01). In girls, cBMI or rBMI did not differ between POMS and NNCs patients (cBMI p = 0.4; rBMI p = 0.44) but with HCs (cBMI +0.99, p < 0.01). CSF inflammatory markers increased with BMI in prepubertal patients (p < 0.01), whereas vitamin D level at diagnosis was lower in boys with higher BMI (p = 0.016). Increased BMI was not associated with clinical and radiologic disease characteristics. Conclusions Overweight and obesity are more frequently observed at diagnosis, particularly in boys with POMS compared with non-neurologic controls and French HCs. Moreover, BMI is related to initial inflammation in the CSF in prepubertal patients with POMS suggesting an interaction between excess body fat, sexual hormones, and POMS occurrence.
Document type :
Journal articles
Complete list of metadata
Contributor : Hal Sorbonne Université Gestionnaire <>
Submitted on : Thursday, July 22, 2021 - 3:24:52 PM
Last modification on : Saturday, August 21, 2021 - 3:24:31 AM


Publication funded by an institution



Pauline Milles, Gianpaolo de Filippo, Hélène Maurey, Thomas Tully, Kumaran Deiva. Obesity in Pediatric-Onset Multiple Sclerosis. Neurology Neuroimmunology & Neuroinflammation, American Academy of neurology, 2021, 8 (5), pp.e1044. ⟨10.1212/nxi.0000000000001044⟩. ⟨hal-03296031⟩



Record views


Files downloads