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Journal Articles Journal of Infectious Diseases Year : 2024

Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study

Margarida Pires Simoes , Emma Hodcroft , Peter Simmonds , Jan Albert , Enagon Alidjinou , Katia Ambert-Balay , Cristina Andrés , Andrés Antón , Christelle Auvray , Jean-Luc Bailly (1) , Fausto Baldanti , Capser Bastings , Stuart Beard , Carla Berengua Pereira , Natasa Berginc , Mandy Bloemen , Soile Blomqvist , Froukje Bosma , Sindy Böttcher , Laura Bubba , Stafan Buderus , Maria Cabrerizo , Christina Calvo , Christina Celma , Ferruccio Ceriotti , Gemma Clark , Inës Costa , Marianne Coste-Burel , Karen Couderé , Jeroen Cremer , Margarita del Cuerpo Casas , Theo Daehne , Jessica de Beer , Maria de Ceano-Vivas , Cillian de Gascun , Alexis de Rougemont , Johnathan Dean , Jennifer Dembinski , Sabine Diedrich , Javier Diez-Domingo , Lena Dillner , Dagny Dorenberg , Alexandra Ducancelle , Susanne Dudman , Robert Dyrdak , Anna-Maria Eis-Huebinger , Iker Falces-Romero , Agnes Farkas , Susan Feeney , Maria Fernandez-Garcia , Jacky Flipse , Kristina Franck , Cristina Galli , Isabelle Garrigue , Felix Geeraedts , Irina Georgieva , Federica Giardina , Raquel Guiomar , Elenor Hauzenberger , Esther Heikens , Cécille Henquell (2) , Didier Hober , Amrio Hönemann , Hannah Howson-Wells , Željka Hruškar , Niina Ikonen , Berthemarie Imbert , Arjan Jansz , Marion Jeannoël , Helena Jiřincová , Laurence Josset , Kathrin Keeren , Naomie Kramer-Lindhout , Sidsel Krokstad , Mouna Lazrek , Hélène Le Guillou-Guillemette , Caroline Lefeuvre , Andreas Lind , Maja Lunar , Melanie Maier , Stéphanie Marque-Juillet , C Patrick Mcclure , James Mckenna , Adam Meijer , Ana Menasalvas Ruiz , Beatriz Mengual-Chuliá , Sofie Midgley , Audrey Mirand (2, 1) , Richard Molenkamp , Milagrosa Montes , Antonio Moreno-Docón , Ursula Morley , Jean-Luc Murk , Ana Navascués-Ortega , Roel Nijhuis , Lubomira Nikolaeva-Glomb , Svein Nordbø , Sanela Numanovic , Massimo Oggioni , Eider Oñate Vergara , Jordi Pacaud , Marie Pacreau , Marcus Panning , Elena Pariani , Lili Pekova , Laura Pellegrinelli , Miroslav Petrovec , Corinna Pietsch , Léa Pilorge , Luis Piñeiro , Antonio Piralla , Mario Poljak , Birgit Prochazka , Nuria Rabella , Janette Rahamat-Langendoen , Petra Rainetova , Marijke Reynders , Annelies Riezebos-Brilman , Lieuwe Roorda , Carita Savolainen-Kopra , Isabelle Schuffenecker , Leo Smeets , Ayse Stoyanova , Karl Stefic (3) , Caroline Swanink , Irena Tabain , Jeroen Tjhie , Luc Thouault , Camille Tumiotto , Sara Uceda Renteria , Tina Uršič , Sophie Vallet , Marc van Ranst , Peter van Wunnik , Jaco Verweij , Jorgina Vila , Bas Wintermans , Elke Wollants , Katja Wolthers , F Xavier López-Labrado , Thea Kolsen Fischer , Heli Harvala , Kimberley Benschop
Margarida Pires Simoes
Emma Hodcroft
Peter Simmonds
Jan Albert
Enagon Alidjinou
  • Function : Author
Katia Ambert-Balay
Cristina Andrés
Andrés Antón
Christelle Auvray
Fausto Baldanti
Capser Bastings
  • Function : Author
Stuart Beard
  • Function : Author
Carla Berengua Pereira
  • Function : Author
Natasa Berginc
  • Function : Author
Mandy Bloemen
  • Function : Author
Soile Blomqvist
  • Function : Author
Froukje Bosma
  • Function : Author
Sindy Böttcher
Laura Bubba
  • Function : Author
Stafan Buderus
  • Function : Author
Maria Cabrerizo
  • Function : Author
Christina Calvo
Christina Celma
  • Function : Author
Ferruccio Ceriotti
Gemma Clark
Inës Costa
Marianne Coste-Burel
  • Function : Author
Karen Couderé
  • Function : Author
Jeroen Cremer
  • Function : Author
Margarita del Cuerpo Casas
  • Function : Author
Theo Daehne
  • Function : Author
Jessica de Beer
  • Function : Author
Maria de Ceano-Vivas
  • Function : Author
Cillian de Gascun
  • Function : Author
Alexis de Rougemont
  • Function : Author
Johnathan Dean
  • Function : Author
Jennifer Dembinski
  • Function : Author
Sabine Diedrich
  • Function : Author
Javier Diez-Domingo
  • Function : Author
Lena Dillner
  • Function : Author
Dagny Dorenberg
  • Function : Author
Alexandra Ducancelle
  • Function : Author
Susanne Dudman
  • Function : Author
Robert Dyrdak
  • Function : Author
Anna-Maria Eis-Huebinger
  • Function : Author
Iker Falces-Romero
Agnes Farkas
  • Function : Author
Susan Feeney
  • Function : Author
Maria Fernandez-Garcia
  • Function : Author
Jacky Flipse
  • Function : Author
Kristina Franck
  • Function : Author
Cristina Galli
  • Function : Author
Isabelle Garrigue
  • Function : Author
Felix Geeraedts
  • Function : Author
Irina Georgieva
  • Function : Author
Federica Giardina
  • Function : Author
Raquel Guiomar
Elenor Hauzenberger
  • Function : Author
Esther Heikens
  • Function : Author
Didier Hober
  • Function : Author
Amrio Hönemann
  • Function : Author
Hannah Howson-Wells
  • Function : Author
Željka Hruškar
  • Function : Author
Niina Ikonen
  • Function : Author
Berthemarie Imbert
  • Function : Author
Arjan Jansz
  • Function : Author
Marion Jeannoël
  • Function : Author
Helena Jiřincová
  • Function : Author
Laurence Josset
  • Function : Author
Kathrin Keeren
  • Function : Author
Naomie Kramer-Lindhout
  • Function : Author
Sidsel Krokstad
  • Function : Author
Mouna Lazrek
  • Function : Author
Caroline Lefeuvre
  • Function : Author
Andreas Lind
  • Function : Author
Maja Lunar
  • Function : Author
Melanie Maier
  • Function : Author
Stéphanie Marque-Juillet
  • Function : Author
C Patrick Mcclure
  • Function : Author
James Mckenna
  • Function : Author
Adam Meijer
Ana Menasalvas Ruiz
  • Function : Author
Beatriz Mengual-Chuliá
  • Function : Author
Sofie Midgley
  • Function : Author
Richard Molenkamp
  • Function : Author
Milagrosa Montes
  • Function : Author
Antonio Moreno-Docón
  • Function : Author
Ursula Morley
  • Function : Author
Jean-Luc Murk
  • Function : Author
Ana Navascués-Ortega
  • Function : Author
Roel Nijhuis
Lubomira Nikolaeva-Glomb
  • Function : Author
Svein Nordbø
  • Function : Author
Sanela Numanovic
  • Function : Author
Massimo Oggioni
  • Function : Author
Eider Oñate Vergara
  • Function : Author
Jordi Pacaud
  • Function : Author
Marie Pacreau
  • Function : Author
Marcus Panning
  • Function : Author
Elena Pariani
  • Function : Author
Lili Pekova
  • Function : Author
Laura Pellegrinelli
  • Function : Author
Miroslav Petrovec
  • Function : Author
Corinna Pietsch
  • Function : Author
Léa Pilorge
  • Function : Author
Luis Piñeiro
  • Function : Author
Antonio Piralla
  • Function : Author
Mario Poljak
  • Function : Author
Birgit Prochazka
  • Function : Author
Nuria Rabella
  • Function : Author
Janette Rahamat-Langendoen
  • Function : Author
Petra Rainetova
  • Function : Author
Marijke Reynders
  • Function : Author
Annelies Riezebos-Brilman
  • Function : Author
Lieuwe Roorda
  • Function : Author
Carita Savolainen-Kopra
  • Function : Author
Isabelle Schuffenecker
  • Function : Author
Leo Smeets
  • Function : Author
Ayse Stoyanova
  • Function : Author
Caroline Swanink
  • Function : Author
Irena Tabain
  • Function : Author
Jeroen Tjhie
  • Function : Author
Luc Thouault
  • Function : Author
Camille Tumiotto
  • Function : Author
Sara Uceda Renteria
Tina Uršič
  • Function : Author
Sophie Vallet
  • Function : Author
Marc van Ranst
  • Function : Author
Peter van Wunnik
  • Function : Author
Jaco Verweij
  • Function : Author
Jorgina Vila
  • Function : Author
Bas Wintermans
  • Function : Author
Elke Wollants
  • Function : Author
Katja Wolthers
  • Function : Author
F Xavier López-Labrado
Thea Kolsen Fischer
Heli Harvala
  • Function : Author
Kimberley Benschop

Abstract

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
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hal-04560143 , version 1 (26-04-2024)

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Margarida Pires Simoes, Emma Hodcroft, Peter Simmonds, Jan Albert, Enagon Alidjinou, et al.. Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study. Journal of Infectious Diseases, inPress, ⟨10.1093/infdis/jiae154⟩. ⟨hal-04560143⟩
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