Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study
Margarida Pires Simoes
,
Emma Hodcroft
,
Peter Simmonds
,
Jan Albert
,
Enagon Alidjinou
,
Katia Ambert-Balay
,
Cristina Andrés
,
Andrés Antón
,
Christelle Auvray
,
Jean-Luc Bailly
(1)
,
Fausto Baldanti
,
Capser Bastings
,
Stuart Beard
,
Carla Berengua Pereira
,
Natasa Berginc
,
Mandy Bloemen
,
Soile Blomqvist
,
Froukje Bosma
,
Sindy Böttcher
,
Laura Bubba
,
Stafan Buderus
,
Maria Cabrerizo
,
Christina Calvo
,
Christina Celma
,
Ferruccio Ceriotti
,
Gemma Clark
,
Inës Costa
,
Marianne Coste-Burel
,
Karen Couderé
,
Jeroen Cremer
,
Margarita del Cuerpo Casas
,
Theo Daehne
,
Jessica de Beer
,
Maria de Ceano-Vivas
,
Cillian de Gascun
,
Alexis de Rougemont
,
Johnathan Dean
,
Jennifer Dembinski
,
Sabine Diedrich
,
Javier Diez-Domingo
,
Lena Dillner
,
Dagny Dorenberg
,
Alexandra Ducancelle
,
Susanne Dudman
,
Robert Dyrdak
,
Anna-Maria Eis-Huebinger
,
Iker Falces-Romero
,
Agnes Farkas
,
Susan Feeney
,
Maria Fernandez-Garcia
,
Jacky Flipse
,
Kristina Franck
,
Cristina Galli
,
Isabelle Garrigue
,
Felix Geeraedts
,
Irina Georgieva
,
Federica Giardina
,
Raquel Guiomar
,
Elenor Hauzenberger
,
Esther Heikens
,
Cécille Henquell
(2)
,
Didier Hober
,
Amrio Hönemann
,
Hannah Howson-Wells
,
Željka Hruškar
,
Niina Ikonen
,
Berthemarie Imbert
,
Arjan Jansz
,
Marion Jeannoël
,
Helena Jiřincová
,
Laurence Josset
,
Kathrin Keeren
,
Naomie Kramer-Lindhout
,
Sidsel Krokstad
,
Mouna Lazrek
,
Hélène Le Guillou-Guillemette
,
Caroline Lefeuvre
,
Andreas Lind
,
Maja Lunar
,
Melanie Maier
,
Stéphanie Marque-Juillet
,
C Patrick Mcclure
,
James Mckenna
,
Adam Meijer
,
Ana Menasalvas Ruiz
,
Beatriz Mengual-Chuliá
,
Sofie Midgley
,
Audrey Mirand
(2, 1)
,
Richard Molenkamp
,
Milagrosa Montes
,
Antonio Moreno-Docón
,
Ursula Morley
,
Jean-Luc Murk
,
Ana Navascués-Ortega
,
Roel Nijhuis
,
Lubomira Nikolaeva-Glomb
,
Svein Nordbø
,
Sanela Numanovic
,
Massimo Oggioni
,
Eider Oñate Vergara
,
Jordi Pacaud
,
Marie Pacreau
,
Marcus Panning
,
Elena Pariani
,
Lili Pekova
,
Laura Pellegrinelli
,
Miroslav Petrovec
,
Corinna Pietsch
,
Léa Pilorge
,
Luis Piñeiro
,
Antonio Piralla
,
Mario Poljak
,
Birgit Prochazka
,
Nuria Rabella
,
Janette Rahamat-Langendoen
,
Petra Rainetova
,
Marijke Reynders
,
Annelies Riezebos-Brilman
,
Lieuwe Roorda
,
Carita Savolainen-Kopra
,
Isabelle Schuffenecker
,
Leo Smeets
,
Ayse Stoyanova
,
Karl Stefic
(3)
,
Caroline Swanink
,
Irena Tabain
,
Jeroen Tjhie
,
Luc Thouault
,
Camille Tumiotto
,
Sara Uceda Renteria
,
Tina Uršič
,
Sophie Vallet
,
Marc van Ranst
,
Peter van Wunnik
,
Jaco Verweij
,
Jorgina Vila
,
Bas Wintermans
,
Elke Wollants
,
Katja Wolthers
,
F Xavier López-Labrado
,
Thea Kolsen Fischer
,
Heli Harvala
,
Kimberley Benschop
Margarida Pires Simoes
- Function : Author
- PersonId : 1378600
- ORCID : 0000-0003-0997-5683
Emma Hodcroft
- Function : Author
- PersonId : 1254745
- ORCID : 0000-0002-0078-2212
Peter Simmonds
- Function : Author
- PersonId : 784833
- ORCID : 0000-0002-7964-4700
Jan Albert
- Function : Author
- PersonId : 1180628
- ORCID : 0000-0001-9020-0521
Enagon Alidjinou
- Function : Author
Katia Ambert-Balay
- Function : Author
- PersonId : 1378601
- ORCID : 0000-0002-2624-712X
Cristina Andrés
- Function : Author
- PersonId : 1378602
- ORCID : 0000-0002-3200-0895
Andrés Antón
- Function : Author
- PersonId : 1378603
- ORCID : 0000-0002-1476-0815
Christelle Auvray
- Function : Author
- PersonId : 1378604
- ORCID : 0000-0001-9782-170X
Jean-Luc Bailly
- Function : Author
- PersonId : 173166
- IdHAL : jean-luc-bailly
- ORCID : 0000-0002-9770-6450
- IdRef : 119683962
Fausto Baldanti
- Function : Author
- PersonId : 1378605
- ORCID : 0000-0001-6559-8099
Capser Bastings
- Function : Author
Stuart Beard
- Function : Author
Carla Berengua Pereira
- Function : Author
Natasa Berginc
- Function : Author
Mandy Bloemen
- Function : Author
Soile Blomqvist
- Function : Author
Froukje Bosma
- Function : Author
Sindy Böttcher
- Function : Author
- PersonId : 1378606
- ORCID : 0000-0002-7521-093X
Laura Bubba
- Function : Author
Stafan Buderus
- Function : Author
Maria Cabrerizo
- Function : Author
Christina Calvo
- Function : Author
- PersonId : 1378607
- ORCID : 0000-0002-6503-3423
Christina Celma
- Function : Author
Ferruccio Ceriotti
- Function : Author
- PersonId : 1233292
- ORCID : 0000-0002-0958-5354
Gemma Clark
- Function : Author
- PersonId : 1378608
- ORCID : 0000-0002-4471-4641
Inës Costa
- Function : Author
- PersonId : 1378609
- ORCID : 0000-0003-2430-0721
Marianne Coste-Burel
- Function : Author
Karen Couderé
- Function : Author
Jeroen Cremer
- Function : Author
Margarita del Cuerpo Casas
- Function : Author
Theo Daehne
- Function : Author
Jessica de Beer
- Function : Author
Maria de Ceano-Vivas
- Function : Author
Cillian de Gascun
- Function : Author
Alexis de Rougemont
- Function : Author
Johnathan Dean
- Function : Author
Jennifer Dembinski
- Function : Author
Sabine Diedrich
- Function : Author
Javier Diez-Domingo
- Function : Author
Lena Dillner
- Function : Author
Dagny Dorenberg
- Function : Author
Alexandra Ducancelle
- Function : Author
Susanne Dudman
- Function : Author
Robert Dyrdak
- Function : Author
Anna-Maria Eis-Huebinger
- Function : Author
Iker Falces-Romero
- Function : Author
- PersonId : 799547
- ORCID : 0000-0001-5888-7706
Agnes Farkas
- Function : Author
Susan Feeney
- Function : Author
Maria Fernandez-Garcia
- Function : Author
Jacky Flipse
- Function : Author
Kristina Franck
- Function : Author
Cristina Galli
- Function : Author
Isabelle Garrigue
- Function : Author
Felix Geeraedts
- Function : Author
Irina Georgieva
- Function : Author
Federica Giardina
- Function : Author
Raquel Guiomar
- Function : Author
- PersonId : 1378610
- ORCID : 0000-0002-4563-6315
Elenor Hauzenberger
- Function : Author
Esther Heikens
- Function : Author
Didier Hober
- Function : Author
Amrio Hönemann
- Function : Author
Hannah Howson-Wells
- Function : Author
Željka Hruškar
- Function : Author
Niina Ikonen
- Function : Author
Berthemarie Imbert
- Function : Author
Arjan Jansz
- Function : Author
Marion Jeannoël
- Function : Author
Helena Jiřincová
- Function : Author
Laurence Josset
- Function : Author
Kathrin Keeren
- Function : Author
Naomie Kramer-Lindhout
- Function : Author
Sidsel Krokstad
- Function : Author
Mouna Lazrek
- Function : Author
Hélène Le Guillou-Guillemette
- Function : Author
Caroline Lefeuvre
- Function : Author
Andreas Lind
- Function : Author
Maja Lunar
- Function : Author
Melanie Maier
- Function : Author
Stéphanie Marque-Juillet
- Function : Author
C Patrick Mcclure
- Function : Author
James Mckenna
- Function : Author
Adam Meijer
- Function : Author
- PersonId : 1378611
- ORCID : 0000-0001-8074-7582
Ana Menasalvas Ruiz
- Function : Author
Beatriz Mengual-Chuliá
- Function : Author
Sofie Midgley
- Function : Author
Richard Molenkamp
- Function : Author
Milagrosa Montes
- Function : Author
Antonio Moreno-Docón
- Function : Author
Ursula Morley
- Function : Author
Jean-Luc Murk
- Function : Author
Ana Navascués-Ortega
- Function : Author
Roel Nijhuis
- Function : Author
- PersonId : 1378612
- ORCID : 0000-0003-4203-3858
Lubomira Nikolaeva-Glomb
- Function : Author
Svein Nordbø
- Function : Author
Sanela Numanovic
- Function : Author
Massimo Oggioni
- Function : Author
Eider Oñate Vergara
- Function : Author
Jordi Pacaud
- Function : Author
Marie Pacreau
- Function : Author
Marcus Panning
- Function : Author
Elena Pariani
- Function : Author
Lili Pekova
- Function : Author
Laura Pellegrinelli
- Function : Author
Miroslav Petrovec
- Function : Author
Corinna Pietsch
- Function : Author
Léa Pilorge
- Function : Author
Luis Piñeiro
- Function : Author
Antonio Piralla
- Function : Author
Mario Poljak
- Function : Author
Birgit Prochazka
- Function : Author
Nuria Rabella
- Function : Author
Janette Rahamat-Langendoen
- Function : Author
Petra Rainetova
- Function : Author
Marijke Reynders
- Function : Author
Annelies Riezebos-Brilman
- Function : Author
Lieuwe Roorda
- Function : Author
Carita Savolainen-Kopra
- Function : Author
Isabelle Schuffenecker
- Function : Author
Leo Smeets
- Function : Author
Ayse Stoyanova
- Function : Author
Karl Stefic
- Function : Author
- PersonId : 1227603
- ORCID : 0000-0002-9686-9194
- IdRef : 196849403
Caroline Swanink
- Function : Author
Irena Tabain
- Function : Author
Jeroen Tjhie
- Function : Author
Luc Thouault
- Function : Author
Camille Tumiotto
- Function : Author
Sara Uceda Renteria
- Function : Author
- PersonId : 1233658
- ORCID : 0000-0002-2027-8478
Tina Uršič
- Function : Author
Sophie Vallet
- Function : Author
Marc van Ranst
- Function : Author
Peter van Wunnik
- Function : Author
Jaco Verweij
- Function : Author
Jorgina Vila
- Function : Author
Bas Wintermans
- Function : Author
Elke Wollants
- Function : Author
Katja Wolthers
- Function : Author
F Xavier López-Labrado
- Function : Author
- PersonId : 1378613
- ORCID : 0000-0002-9403-8258
Thea Kolsen Fischer
- Function : Author
- PersonId : 1378593
- ORCID : 0000-0003-4812-980X
Heli Harvala
- Function : Author
Kimberley Benschop
- Function : Author
- PersonId : 1378586
- ORCID : 0000-0002-8328-0882
Abstract
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
Origin : Publication funded by an institution