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Étude de la composante génétique de l’efficience alimentaire (EA) chez des lignées de poules pondeuses divergentes pour l’EA en utilisant la technologie RNA-seq

Abstract : Feed efficiency (FE) is an important trait of agronomical interest. The variation of FE in a population is mainly due to the variation of gene expression, itself due to variants that regulate them in cis. This thesis had three interconnected objectives.The 1st was to study the tissues and genes involved in the difference in FE between two different strains of layers divergent for this trait. To this end, we studied transcriptomes from four tissues (adipose tissue, blood, hypothalamus and liver) using the possibilities offered by RNA-seq, an RNA sequencing technology.The 2nd objective was to contribute to the functional annotation of the chicken genome by enriching its annotation with long non-coding RNA genes, important expression regulators. We also detected SNPs by RNA-seq, a necessary step in the establishment of a pipeline for the study of allele-specific expression, a marker of cis-regulation.The 3rd objective combined the results of previous work to identify candidate genes that cause FE variation due to a variant impacting the structure of the RNA or associated protein, or a cis-regulatory variant.
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https://tel.archives-ouvertes.fr/tel-03462775
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Submitted on : Thursday, December 2, 2021 - 9:26:42 AM
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  • HAL Id : tel-03462775, version 1

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Frédéric Jehl. Étude de la composante génétique de l’efficience alimentaire (EA) chez des lignées de poules pondeuses divergentes pour l’EA en utilisant la technologie RNA-seq. Génétique animale. Institut Agro - Agrocampus Ouest, 2020. Français. ⟨NNT : 2020NSARV150⟩. ⟨tel-03462775⟩

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