Abstract : This paper discusses the electrical sensing of red blood cell (RBC) rigidity due to Hemoglobin S (HbS) polymerization in sickle cell disease. For this purpose sickle RBCs subpopulations, differentiated by cell density, were flown through a microfluidic device equipped with integrated microelectrodes. Differences in transit time and electrical blockade were observed and analyzed.
https://hal.archives-ouvertes.fr/hal-03078878 Contributor : Bruno Le PioufleConnect in order to contact the contributor Submitted on : Monday, January 4, 2021 - 5:43:22 PM Last modification on : Tuesday, May 10, 2022 - 2:38:04 PM Long-term archiving on: : Monday, April 5, 2021 - 6:39:57 PM
Tieying Xu, Maria A Lizarralde-Iragorri, Jean Roman, Emile Martincic, Valentine Brousse, et al.. Electrical Sensing of sickled red blood cells subpopulations in microfluidic device. MicroTAS, Oct 2020, on-line, France. ⟨hal-03078878⟩