Electrical Sensing of sickled red blood cells subpopulations in microfluidic device

This paper discusses the electrical sensing of red blood cell (RBC) rigidity due to Hemoglobin S (HbS) polymerization in sickle cell disease. For this purpose sickle RBCs subpopulations, differentiated by cell density, were flown through a microfluidic device equipped with integrated microelectrodes. Differences in transit time and electrical blockade were observed and analyzed.

Keywords

Sickle Cell Disease Electrical Sensing Microfluidic

Domains

Micro and nanotechnologies/Microelectronics Life Sciences [q-bio]

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MicroTAS_2020_XU.pdf (409.01 Ko)

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https://hal.science/hal-03078878

Submitted on : Monday, January 4, 2021-5:43:22 PM

Last modification on : Monday, April 3, 2023-9:04:42 AM

Long-term archiving on: Monday, April 5, 2021-6:39:57 PM

Dates and versions

hal-03078878 , version 1 (04-01-2021)

Identifiers

HAL Id : hal-03078878 , version 1

Cite

Tieying Xu, Maria A Lizarralde-Iragorri, Jean Roman, Emile Martincic, Valentine Brousse, et al.. Electrical Sensing of sickled red blood cells subpopulations in microfluidic device. MicroTAS, Oct 2020, on-line, France. ⟨hal-03078878⟩

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