Article Dans Une Revue Histopathology Année : 2024

Follicular lymphoma research: an open dialogue for a collaborative roadmap

Résumé

Follicular lymphoma (FL) is the second most common type of lymphoma (20% of all non‐Hodgkin lymphomas), derived from germinal centre (GC) B cells, and is characterised by its significant clinical, prognostic and biological heterogeneity, leading to complexity in management. Despite significant biological investigation and indisputable clinical progress since the advent of the immunotherapy era more than 20 years ago, much remains to be done to understand and cure this lymphoma. Today, FL is metaphorically a giant puzzle on the table with patches of sky, landscape and foliage clearly appearing. However, many of the remaining pieces are held by various stakeholders (e.g. clinicians, pathologists, researchers, drug developers) without global agreement on what the gaps are, or any clear blueprint on how to solve the puzzle of understanding the heterogeneity of this disease and create curative and tailored therapies. With the advent of new investigation and drug technologies, together with recent advances in our capacity to manage big data, the time seems ripe for a change of scale. More than ever, this will require collaboration between and within all stakeholders to overcome the current bottlenecks in the field. As for every investigator, we acknowledge that this first draft is necessarily biased, incomplete and some FL expert readers might recognise some remaining gaps not addressed. We hope they will reply to make this effort a collaborative one to assemble all the pieces in the most ideal fashion. As such, this review intends to be a first step and an interactive platform to a collaborative roadmap towards better understanding and care of FL.

Mots clés

World Health Organisation ZO zanubrutinib in combinationwith obinutuzumab antigen AI artificial intelligence BCL B cell lymphoma BCR B cell receptor BM bone marrow CAR-T chimeric antigen receptor T COO cell of origin cFL constrained FL CMG chromatin modifying genes CPC cancer progenitor cells CRR complete response rate ctDNA circulating cell-free tumour DNA DZ dark zone dFL DLBCL-like FL DLBCL diffuselarge B cell lymphoma FFPE Formalin-fixedparaffin-embedded FL follicularlymphoma FLIPI FL international prognosticindex GC germinalcenters GOF gain-offunction ICT immunochemotherapy Ig immunoglobulin LOF loss of function LZ light zone MRD minimal residual disease NHL non-Hodgkin lymphoma ORR overall response rate OS overall survival PFS progression-free survival POD24 progression of disease within 24months of treatment PRC2 polycomb repressive complex 2 RISC relapse-initiating subclones RT-PCR reversetranscription-polymerase chain reaction RR relapse/refractory SHM somatic hypermutation SLO secondary lymphoid organs SOC standard of care TFH T follicular helper cell tFL transformed FL TME tumour microenvironment TNF tumour necrosis factor WHO World Health Organisation ZO Ag antigen AI artificial intelligence BCL B cell lymphoma BCR B cell receptor BM bone marrow CAR-T chimeric antigen receptor T COO cell of origin cFL constrained FL CMG chromatin modifying genes CPC cancer progenitor cells CRR complete response rate ctDNA circulating cell-free tumour DNA DZ dark zone dFL DLBCL-like FL DLBCL diffuselarge B cell lymphoma FFPE Formalin-fixedparaffin-embedded FL follicularlymphoma FLIPI FL international prognosticindex GC germinalcenters GOF gain-offunction ICT immunochemotherapy Ig immunoglobulin LOF loss of function LZ light zone MRD minimal residual disease NHL non-Hodgkin lymphoma ORR overall response rate OS overall survival PFS progression-free survival POD24 progression of disease within 24months of treatment PRC2 polycomb repressive complex 2 RISC relapse-initiating subclones RT-PCR reversetranscription-polymerase chain reaction RR relapse/refractory SHM somatic hypermutation SLO secondary lymphoid organs SOC standard of care TFH T follicular helper cell tFL transformed FL TME tumour microenvironment TNF tumour necrosis factor WHO

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https://amu.hal.science/hal-04945792

Soumis le : jeudi 13 février 2025-14:00:22

Dernière modification le : vendredi 14 février 2025-03:27:58

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hal-04945792 , version 1 (13-02-2025)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Mélanie Collin, Guillemette Gagey, Vignesh Shanmugam, Abner Louissaint, Jessica Okosun, et al.. Follicular lymphoma research: an open dialogue for a collaborative roadmap. Histopathology, 2024, 86 (1), pp.79-93. ⟨10.1111/his.15344⟩. ⟨hal-04945792⟩

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