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Neutral Peptides in the Gas Phase: Conformation and Aggregation Issues

Eric Gloaguen 1, 2, 3 Michel Mons 1, 2, 3 Kirsten Schwing 4 Markus Gerhards 4
2 SBM - Structures BioMoléculaires
IRAMIS - Institut Rayonnement Matière de Saclay, LIDyl - Laboratoire Interactions, Dynamiques et Lasers (ex SPAM)
3 LUMO - LUmière et MOlécules
IRAMIS - Institut Rayonnement Matière de Saclay, LIDyl - Laboratoire Interactions, Dynamiques et Lasers (ex SPAM)
Abstract : Combined IR and UV laser spectroscopic techniques in molecular beams merged with theoretical approaches have proven to be an ideal tool to elucidate intrinsic structural properties on a molecular level. It offers the possibility to analyze structural changes, in a controlled molecular environment, when successively adding aggregation partners. By this, it further makes these techniques a valuable starting point for a bottom-up approach in understanding the forces shaping larger molecular systems. This bottom-up approach was successfully applied to neutral amino acids starting around the 1990s. Ever since, experimental and theoretical methods developed further, and investigations could be extended to larger peptide systems. Against this background, the review gives an introduction to secondary structures and experimental methods as well as a summary on theoretical approaches. Vibrational frequencies being characteristic probes of molecular structure and interactions are especially addressed. Archetypal biologically relevant secondary structures investigated by molecular beam spectroscopy are described, and the influences of specific peptide residues on conformational preferences as well as the competition between secondary structures are discussed. Important influences like microsolvation or aggregation behavior are presented. Beyond the linear α-peptides, the main results of structural analysis on cyclic systems as well as on βand γ-peptides are summarized. Overall, this contribution addresses current aspects of molecular beam spectroscopy on peptides and related species and provides molecular level insights into manifold issues of chemical and biochemical relevance.
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Contributor : Eric Gloaguen <>
Submitted on : Wednesday, July 21, 2021 - 10:07:57 AM
Last modification on : Thursday, July 29, 2021 - 3:00:42 PM

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Eric Gloaguen, Michel Mons, Kirsten Schwing, Markus Gerhards. Neutral Peptides in the Gas Phase: Conformation and Aggregation Issues. Chemical Reviews, American Chemical Society, 2020, 120 (22), pp.12490-12562. ⟨10.1021/acs.chemrev.0c00168⟩. ⟨hal-03293514⟩

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